主页 / 药理学 / GPCRs / 7-TM Receptors / 5-HT Receptors / 5-HT6 Receptors / 5-HT6 Receptor Agonists / WAY 181187 oxalate

WAY 181187 oxalate

Cat. No. 5589 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity and selective 5-HT6 agonist
化学名： 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WAY 181187 oxalate

WAY 181187 oxalate is a high affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc

化合物库 for WAY 181187 oxalate

WAY 181187 oxalate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 181187 oxalate

分子量 470.91
公式 C15H13ClN4O2S2.C2H2O4
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1883548-85-3
PubChem ID 121513871
InChI Key KAFVDFYVWBASDD-UHFFFAOYSA-N
Smiles NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 181187 oxalate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.09 100

制备储备液 for WAY 181187 oxalate

以下数据基于产品分子量 470.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.62 mL 21.24 mL
5 mM 0.42 mL 2.12 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for WAY 181187 oxalate

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WAY 181187 oxalate

参考文献是支持产品生物活性的出版物。

Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID: 25837696

Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID: 17948978

If you know of a relevant reference for WAY 181187 oxalate, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 5-HT6 Receptor Agonists

关键词: WAY 181187 oxalate, WAY 181187 oxalate supplier, WAY181187, oxalate, 554403-49-5, High, affinity, and, selective, 5-HT6, agonists, activates, sleep, serotonin, receptors, serotonergic, Receptors, 5589, Tocris Bioscience

2 篇 WAY 181187 oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WAY 181187 oxalate 的部分引用包括：

David E et al (2022) A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 185 3390-3407.e18 PMID: 36055200

Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714

您是否知道使用了 Tocris WAY 181187 oxalate 的优秀论文？ 请告知我们.

WAY 181187 oxalate 的评论

目前没有该产品的评论。 Be the first to review WAY 181187 oxalate and earn rewards!

Have you used WAY 181187 oxalate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.