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WAY 208466 dihydrochloride

Cat. No. 3904 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective 5-HT6 agonist
化学名： 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is a high affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 208466 dihydrochloride

分子量 420.33
公式 C17H18FN3O2S.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1207064-61-6
PubChem ID 22028182
InChI Key BAOHMLBVCLITHA-UHFFFAOYSA-N
Smiles O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 208466 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 33.63 80
DMSO 33.63 80

制备储备液 for WAY 208466 dihydrochloride

以下数据基于产品分子量 420.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.8 mM 2.97 mL 14.87 mL 29.74 mL
4 mM 0.59 mL 2.97 mL 5.95 mL
8 mM 0.3 mL 1.49 mL 2.97 mL
40 mM 0.06 mL 0.3 mL 0.59 mL

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产品说明书 for WAY 208466 dihydrochloride

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化学品安全技术说明书

参考文献 for WAY 208466 dihydrochloride

参考文献是支持产品生物活性的出版物。

Schechter et al (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 33 1323 PMID: 17625499

Carr et al (2010) Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 213 49 PMID: 20217056

If you know of a relevant reference for WAY 208466 dihydrochloride, please let us know.

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关键词: WAY 208466 dihydrochloride, WAY 208466 dihydrochloride supplier, WAY208466, 2HCl, serotonin, receptor, subtype, 5-hydroxytryptamine, 6, agonist, 5-HT6, agonists, Receptors, 3904, Tocris Bioscience

1 篇 WAY 208466 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WAY 208466 dihydrochloride 的部分引用包括：

Sun et al (2018) Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson's disease. Neuropharmacology 137 275 PMID: 29778944

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