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WAY 252623

Cat. No. 5951 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent LXR agonist
化学名： 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WAY 252623

WAY 252623 is a potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for WAY 252623

WAY 252623 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 252623

分子量 422.78
公式 C21H12ClF5N2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 875787-07-8
PubChem ID 16734800
InChI Key KYWWJENKIMRJBI-UHFFFAOYSA-N
Smiles ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 252623

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.28 100
ethanol 42.28 100

制备储备液 for WAY 252623

以下数据基于产品分子量 422.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.83 mL 23.65 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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参考文献 for WAY 252623

参考文献是支持产品生物活性的出版物。

DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6 PMID: 18925943

Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358 PMID: 19318684

If you know of a relevant reference for WAY 252623, please let us know.

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关键词: WAY 252623, WAY 252623 supplier, WAY252623, LXR, liver, X, receptor, alpha, beta, LXRa, LXRb, β, α, potent, agonists, agonism, orally, bioavailable, LXR-like, Receptors, 5951, Tocris Bioscience

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