WIN 64338 hydrochloride

Cat. No. 1057 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Bradykinin B₂ antagonist

化学名： (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for WIN 64338 hydrochloride

WIN 64338 hydrochloride is a the first potent, non-peptide, competitive bradykinin B₂ receptor antagonist. In organ bath studies, WIN 64338 inhibits [³H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B₁ preparation).

技术数据 for WIN 64338 hydrochloride

分子量	783.95
公式	C₄₅H₆₈ClN₄OP.HCl
储存	Desiccate at +4°C
CAS Number	163727-74-0
PubChem ID	9832172
InChI Key	YYJGBEZPVOUBMJ-KRFCICRISA-N
Smiles	CCCC[P+](CCCC)(CC1=CC=C(C=C1)NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC5=CC=CC=C5C=C4)=O)CCCC.Cl.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WIN 64338 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	58.8	75

制备储备液 for WIN 64338 hydrochloride

以下数据基于产品分子量 783.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.75 mM	1.7 mL	8.5 mL	17.01 mL
3.75 mM	0.34 mL	1.7 mL	3.4 mL
7.5 mM	0.17 mL	0.85 mL	1.7 mL
37.5 mM	0.03 mL	0.17 mL	0.34 mL

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产品说明书 for WIN 64338 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WIN 64338 hydrochloride

参考文献是支持产品生物活性的出版物。

Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600

Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B₂ receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B₂ receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533

If you know of a relevant reference for WIN 64338 hydrochloride, please let us know.

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关键词: WIN 64338 hydrochloride, WIN 64338 hydrochloride supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, 1057, Tocris Bioscience

1 篇 WIN 64338 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WIN 64338 hydrochloride 的部分引用包括：

Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38 PMID: 22407888

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