WKYMVm

Cat. No. 1800 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： FPR1, FPR2 and FPR3 receptor agonist

别名： Leukocyte chemoattractant peptide

纯度： ≥95% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for WKYMVm

WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC₅₀ = 75 pM) and FPR3 (EC₅₀ = 3 nM), expressed on immune cells. Induces Ca²⁺ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

技术数据 for WKYMVm

分子量	856.11
公式	C₄₁H₆₁N₉O₇S₂
序列	WKYMVM (Modifications: Met-6 = D-Met & C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	187986-17-0
PubChem ID	457933
InChI Key	FMBGOORJEKQQLG-JUZZZACGSA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WKYMVm

溶解性	Soluble to 2 mg/ml in water

产品说明书 for WKYMVm

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WKYMVm

参考文献是支持产品生物活性的出版物。

Bae et al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329 PMID: 11818455

Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH₂ specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256

Le et al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777 PMID: 10586077

If you know of a relevant reference for WKYMVm, please let us know.

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关键词: WKYMVm, WKYMVm supplier, FPR1, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Leukocyte, chemoattractant, peptide, 1800, Tocris Bioscience