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说明： Selective FPR2 and FPR3 receptor agonist
别名： W-peptide
生物活性 for WKYMVM
WKYMVM is a selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
技术数据 for WKYMVM
| 分子量 | 856.11 |
| 公式 | C41H61N9O7S2 |
| 序列 |
WKYMVM (Modifications: Met-6 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 187986-11-4 |
| PubChem ID | 68661247 |
| InChI Key | FMBGOORJEKQQLG-LXOXETEGSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WKYMVM
参考文献 for WKYMVM
参考文献是支持产品生物活性的出版物。
Baek et al (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. J.Biol.Chem. 271 8170 PMID: 8626507
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256
Christophe et al (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin. Scand.J.Immunol. 56 470 PMID: 12410796
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关键词: WKYMVM, WKYMVM supplier, Selective, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, W-peptide, 1799, Tocris Bioscience
5 篇 WKYMVM 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WKYMVM 的部分引用包括：
Schepetkin et al (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol 92 627 PMID: 25450672
Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol 79 77 PMID: 20943772
Schepetkin et al (2013) 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2. Biochem Pharmacol 85 404 PMID: 23219934
Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo Science 372 PMID: 34140358
García-Prieto et al (2017) Neutrophil stunning by MP reduces infarct size. Nat Commun 8 14780 PMID: 28416795
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