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WNTinib

Cat. No. 8106 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of mutant β-catenin signaling in hepatocellular carcinoma
化学名： 4-[3-Fluoro-4-[[[[4-(1,1,2,2,2-pentafluoroethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WNTinib

WNTinib is a multi-kinase inhibitor with selectivity for mutant β-catenin (CTNNB1) in hepatocellular carcinoma compared to wild type hepatocytes (IC50 ranges are 0.36 μM-0.54 μM in primary organoids; 0.28 μM-1 μM in primary human HCC cell lines and 0.45 μM-2.3 μM in human cell lines ). Also inhibits VEGFR2, PDE6D and VEGFR1 (IC50 values are 0.3 μM, 0.3 μM and 0.6 μM respectively). Downregulates WNT and phospho-EZH2, upregulates trimethylation of H3K27 and normalises expression of apoptotic genes.

技术数据 for WNTinib

分子量 498.39
公式 C22H16F6N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2770091-44-4
PubChem ID 170535525
InChI Key URCPDENSDRVZDE-UHFFFAOYSA-N
Smiles O=C(NC1=CC=C(C=C1F)OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(C(F)(C(F)(F)F)F)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WNTinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.84 100

制备储备液 for WNTinib

以下数据基于产品分子量 498.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL
10 mM 0.2 mL 1 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for WNTinib

参考文献是支持产品生物活性的出版物。

Rialdi et al (2023) WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nat.Cancer 4 1157 PMID: 37537299

If you know of a relevant reference for WNTinib, please let us know.

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关键词: WNTinib, WNTinib supplier, Wnt, beta-catenin, b-catenin, catenin, CTNNB1, mutant, hepatocellular, carcinoma, kinase, inhibitor, inhibitors, Beta-catenin, 8106, Tocris Bioscience

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Pathways for WNTinib

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.