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WQ 1

Cat. No. 7156 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective σ1 receptor antagonist; active in vivo
别名： TC WQ 1,TC Sigma1
化学名： 2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WQ 1

WQ 1 is a high affinity and selective σ1 receptor antagonist (pKi values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.

化合物库 for WQ 1

WQ 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WQ 1

分子量 337.48
公式 C21H23NOS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1204401-49-9
InChI Key XWMHOCDNGHEUMF-UHFFFAOYSA-N
Smiles O=C(C1=CC=CC=C1S2)CC2C3CCN(CC4=CC=CC=C4)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WQ 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.87 50
ethanol 3.37 10

制备储备液 for WQ 1

以下数据基于产品分子量 337.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.93 mL 29.63 mL 59.26 mL
2.5 mM 1.19 mL 5.93 mL 11.85 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
25 mM 0.12 mL 0.59 mL 1.19 mL

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参考文献 for WQ 1

参考文献是支持产品生物活性的出版物。

Bello et al (2019) Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 10 3391 PMID: 31298830

Piergentili et al (2010) Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 53 1261 PMID: 20067271

If you know of a relevant reference for WQ 1, please let us know.

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关键词: WQ 1, WQ 1 supplier, WQ1, s1, sigma1, antagonists, Receptors, σ1, TC, WQ, 1, Sigma1, 7156, Tocris Bioscience

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