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Submit ReviewWRW4
说明： Selective FPR2 antagonist
别名： WRW4
纯度： ≥95% (HPLC)
生物活性 for WRW4
WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
技术数据 for WRW4
| 分子量 | 1104.28 |
| 公式 | C61H65N15O6 |
| 序列 |
WRWWWW (Modification: Trp-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 878557-55-2 |
| PubChem ID | 49768327 |
| InChI Key | IRJDOVLLPORVJP-WOAIKHIASA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for WRW4
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for WRW4
参考文献 for WRW4
参考文献是支持产品生物活性的出版物。
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823
If you know of a relevant reference for WRW4, please let us know.
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关键词: WRW4, WRW4 supplier, Selective, FPR2, antagonists, FPRL, Formyl, Peptide, Receptors, WRW4, 2262, Tocris Bioscience
9 篇 WRW4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WRW4 的部分引用包括：
Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372 1262 PMID: 34140358
Barnig et al (2013) Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 5 174ra26 PMID: 23447017
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962
Tristão et al (2013) 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun 81 1256 PMID: 23381993
Wenceslau et al (2015) Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome. Am J Physiol Heart Circ Physiol 308 H768 PMID: 25637548
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
Rhys et al (2018) Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine 29 60 PMID: 29449195
Hasan et al (2014) Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. BMC Mol Biol 18 497 PMID: 25598664
Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Korean J Physiol Pharmacol 25 483 PMID: 20930115
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WRW4 的评论
平均评分: 3 (Based on 1 Review.)
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it's ok.
By
Christopher Durrant on 01/09/2020
分析类型： Ex Vivo
种属： Human
for formyl peptide receptor 2 (FPR2) signaling
Followed publication, it worked, great