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WWL 123

Cat. No. 5317 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic
化学名： N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WWL 123

WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB1 and CB2 receptors, but is GABAA receptor dependent. Brain penetrant.

Other Information for WWL 123

There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.

化合物库 for WWL 123

WWL 123 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WWL 123

分子量 436.5
公式 C28H24N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1338574-83-6
PubChem ID 90209976
InChI Key UUJGYRHAOHORFC-UHFFFAOYSA-N
Smiles NC(C1=CC=C(C2=CC=C(OC(N(C)CC3=CC(C4=CC=CC=C4)=CC=C3)=O)C=C2)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WWL 123

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.65 100

制备储备液 for WWL 123

以下数据基于产品分子量 436.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for WWL 123

参考文献是支持产品生物活性的出版物。

Naydenov et al (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83 361 PMID: 25033180

If you know of a relevant reference for WWL 123, please let us know.

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关键词: WWL 123, WWL 123 supplier, WWL123, epilepsy, antiepileptics, anticonvulsants, alpha, beta, hydrolase, domain, 6, ABHD6, GABAA, α, β, ahydrolase, alphahydrolase, inhibits, inhibitors, Other, Hydrolases, 5317, Tocris Bioscience

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