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WY 14643

Cat. No. 1312 12 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective PPARα agonist
化学名： [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (12)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WY 14643

WY 14643 is a selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

化合物库 for WY 14643

WY 14643 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WY 14643

分子量 323.8
公式 C14H14ClN3O2S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 50892-23-4
PubChem ID 5694
InChI Key SZRPDCCEHVWOJX-UHFFFAOYSA-N
Smiles CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WY 14643

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.38 100

制备储备液 for WY 14643

以下数据基于产品分子量 323.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.44 mL 30.88 mL
5 mM 0.62 mL 3.09 mL 6.18 mL
10 mM 0.31 mL 1.54 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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产品说明书 for WY 14643

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WY 14643

参考文献是支持产品生物活性的出版物。

Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077

Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 94 4312 PMID: 9113986

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680

If you know of a relevant reference for WY 14643, please let us know.

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关键词: WY 14643, WY 14643 supplier, Selective, PPARα, PPARalpha, agonists, Peroxisome-Proliferator, Receptors, PPARs, WY14643, 1312, Tocris Bioscience

12 篇 WY 14643 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WY 14643 的部分引用包括：

Puligheddu et al (2013) PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS One 8 e64541 PMID: 23724059

Strand et al (2019) Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats. PPAR Res 2019 8047627 PMID: 31308847

Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048 PMID: 25848047

Mascia et al (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69 633 PMID: 20801430

Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors. J Neurosci 28 13985 PMID: 19091987

Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Mol Psychiatry 339 886 PMID: 21896918

Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144 PMID: 24050945

Ropero et al (2009) Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200 127 PMID: 19017711

Lee et al (2018) Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med 7 PMID: 30486372

Lee et al (2004) Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. Biochem J 378 983 PMID: 14641110

Smith et al (2019) Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl) PMID: 31119329

Neuhaus et al (2017) Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury. Front Mol Neurosci 10 149 PMID: 28603485

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