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WZ 4002

Cat. No. 6290 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent mutant-selective EGFR inhibitor
化学名： N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WZ 4002

WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.

许可信息

Sold under license from Dana-Farber Cancer Institute.

技术数据 for WZ 4002

分子量 494.98
公式 C25H27ClN6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1213269-23-8
PubChem ID 44607530
InChI Key ITTRLTNMFYIYPA-UHFFFAOYSA-N
Smiles COC1=C(NC2=NC=C(Cl)C(OC3=CC(NC(C=C)=O)=CC=C3)=N2)C=CC(N4CCN(C)CC4)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WZ 4002

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.95 10

制备储备液 for WZ 4002

以下数据基于产品分子量 494.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 20.2 mL 101.01 mL 202.03 mL
0.5 mM 4.04 mL 20.2 mL 40.41 mL
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

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参考文献 for WZ 4002

参考文献是支持产品生物活性的出版物。

Zhou et al (2009) Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462 1070 PMID: 20033049

If you know of a relevant reference for WZ 4002, please let us know.

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关键词: WZ 4002, WZ 4002 supplier, WZ4002, potent, EGFR, epidermal, growth, factor, receptor, tyrosine, kinase, inhibitors, inhibits, mutant-selective, T790M, L858R, 6290, Tocris Bioscience

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