Xanomeline oxalate

Cat. No. 3569 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Functionally biased muscarinic M4 receptor agonist

化学名： 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Xanomeline oxalate

Xanomeline oxalate is a functionally biased muscarinic M₄ receptor agonist (EC₅₀ values are 14.1 nM, 30.9 nM, 1700 nM, 1800 nM and 8500 nM at M₄, M₁, M₂, M₅ and M₃ receptors respectively. Binds with similar affinity to all muscarinic acetylcholine receptors (pKi 6.7-7.7) but displays higher efficacy and efficacy-driven selectivity at M₄ receptors. Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M₁; delayed wash-resistant partial agonist activity at M₂; and delayed wash-resistant full agonist activity at M₄. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

化合物库 for Xanomeline oxalate

Xanomeline oxalate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Xanomeline oxalate

分子量	371.46
公式	C₁₄H₂₃N₃OS.C₂H₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	141064-23-5
PubChem ID	18920248
InChI Key	ZJOUESNWCLASJP-UHFFFAOYSA-N
Smiles	CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Xanomeline oxalate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.71	10 温和加热
	DMSO	37.15	100

制备储备液 for Xanomeline oxalate

以下数据基于产品分子量 371.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for Xanomeline oxalate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Xanomeline oxalate

参考文献是支持产品生物活性的出版物。

et al (2009) Pharmacological Eur.J.Pharmacol. 53 et al (2023) Structural Nat.Chem.Biol. 805 Jakubik and prospects for design of selective muscarinic agonists. 57 PMID: 18481916

ht">Heinrich comparison of muscarinic ligands: historical versus more recent muscarinic M₁-preferring receptor agonists. 605 PMID: 19168056

ht">Stanhope receptor agonist xanomeline has an antipsychotic-like profile in the rat. 299 PMID: 11602695

ht">Powers basis of efficacy-driven ligand selectivity at GPCRs. 19 PMID: 36782010

ht">McDonald of xanomeline at the recombinant human M₄ muscarinic acetylcholine receptor. 13 PMID: 35380782 know of a relevant reference for Xanomeline oxalate, please let us know.

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关键词: Xanomeline oxalate, Xanomeline oxalate supplier, Functionally, biased, M1, agonists, agonist, Muscarinic, Receptors, Acetylcholine, ACh, machr, M4, alzheimers, schizophrenia, antipsychotic, 3569, Tocris Bioscience

2 篇 Xanomeline oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Xanomeline oxalate 的部分引用包括：

Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063

Tian et al (2016) STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit Scientific Reports 6 36684 PMID: 27857196

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