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XY 018

Cat. No. 6223 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： RORγ antagonist; inhibits AR expression
化学名： N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for XY 018

XY 018 is a RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.

化合物库 for XY 018

XY 018 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for XY 018

分子量 516.36
公式 C23H15F7N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1873358-87-2
PubChem ID 130248006
InChI Key MNVXADPCMINSEC-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C1=CC(F)=C(C2=CC=C(C=C2)NC(CC3=C([N+]([O-])=O)C=CC=C3)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XY 018

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.64 100
ethanol 51.64 100

制备储备液 for XY 018

以下数据基于产品分子量 516.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.37 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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参考文献 for XY 018

参考文献是支持产品生物活性的出版物。

Wang et al (2016) ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 22 488 PMID: 27019329

Ndagi et al (2018) Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein. J.Biomol.Struct.Dyn. 36 335 PMID: 28027708

If you know of a relevant reference for XY 018, please let us know.

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关键词: XY 018, XY 018 supplier, XY018, retinoic, acid, related, orphan, receptor, ROR, gamma, antagonists, antagonism, inhibitors, inhibits, AR, androgen, expression, Retinoic, Acid-related, Orphan, Receptors, Androgen, Receptor, 6223, Tocris Bioscience

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