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Submit ReviewY-25130 hydrochloride
说明： Potent and selective 5-HT3 antagonist
化学名： N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Y-25130 hydrochloride
Y-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
技术数据 for Y-25130 hydrochloride
| 分子量 | 386.28 |
| 公式 | C17H20ClN3O3.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 123040-16-4 |
| PubChem ID | 115000 |
| InChI Key | DBMKBKPJYAHLQP-UHFFFAOYSA-N |
| Smiles | Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Y-25130 hydrochloride
参考文献 for Y-25130 hydrochloride
参考文献是支持产品生物活性的出版物。
Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299 PMID: 1654255
Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377 PMID: 8107329
Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443 PMID: 1331590
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关键词: Y-25130 hydrochloride, Y-25130 hydrochloride supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors, 0380, Tocris Bioscience
2 篇 Y-25130 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Y-25130 hydrochloride 的部分引用包括：
Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A 4 12 PMID: 18416824
Sándor et al (2018) Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Front Pharmacol 9 323 PMID: 29681854
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.