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Yhhu 3792

Cat. No. 6599 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
化学名： 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Yhhu 3792

Yhhu 3792 is a notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.

化合物库 for Yhhu 3792

Yhhu 3792 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Yhhu 3792

分子量 436.93
公式 C24H24N4O2.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2624336-93-0
InChI Key WNNJMAWCEOKXEJ-UHFFFAOYSA-N
Smiles COC1=CC=CC(OC2=CC=CC3=C2C(N)=NC(NC4=CC=C(C(C)C)C=C4)=N3)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Yhhu 3792

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.69 100

制备储备液 for Yhhu 3792

以下数据基于产品分子量 436.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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产品说明书 for Yhhu 3792

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参考文献 for Yhhu 3792

参考文献是支持产品生物活性的出版物。

Lu (2018) A novel 2-phenylamino-quinazoline-based compound expands the neural stem cell pool and promotes the hippocampal neurogenesis and the cognitive ability of adult mice. Stem Cells 36 1273 PMID: 29726088

If you know of a relevant reference for Yhhu 3792, please let us know.

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关键词: Yhhu 3792, Yhhu 3792 supplier, Yhhu3792, Notch, signaling, pathway, activators, activates, neural, stem, cells, NSCs, memory, in, vivo, Other, Signaling, Stem, Cell, Proliferation, 6599, Tocris Bioscience

1 篇 Yhhu 3792 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Yhhu 3792 的部分引用包括：

Srustidhar et al (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal Immunol 15 940-951 PMID: 35840681

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