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Submit ReviewYM 298198 hydrochloride
Discontinued Product
2448 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Highly potent, selective non-competitive mGlu1 antagonist
化学名： 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for YM 298198 hydrochloride
YM 298198 hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM); inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice.
Desmethyl Derivative also available.
许可信息
Sold with the permission of Astellas Pharma Inc.
技术数据 for YM 298198 hydrochloride
| 分子量 | 378.92 |
| 公式 | C18H22N4OS.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1216398-09-2 |
| PubChem ID | 45073464 |
| InChI Key | WYTJVUVCSUWZTH-UHFFFAOYSA-N |
| Smiles | Cl.CN(C1CCCCC1)C(=O)C1=C(C)N2C(S1)=NC1=CC=C(N)C=C21 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 298198 hydrochloride
参考文献 for YM 298198 hydrochloride
参考文献是支持产品生物活性的出版物。
Kohara et al (2005) Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabo J.Pharmacol.Exp.Ther. 315 163 PMID: 15976016
Emery et al (2010) The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, β-arrestin-1-dependent ERK phosphorylation. J.Biol.Chem. 285 26041 PMID: 20566651
关键词: YM 298198 hydrochloride, YM 298198 hydrochloride supplier, potent, selective, non-competitive, mGlu1, mGluR1, antagonists, Group, I, Receptors, Glutamate, Metabotropic, YM298198, hydrochloride, (Metabotropic), 2448, Tocris Bioscience
1 篇 YM 298198 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 YM 298198 hydrochloride 的部分引用包括：
Yasuda et al (2018) Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction. Front Cell Neurosci 12 330 PMID: 30349460
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