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Submit ReviewYM 750
Discontinued Product
3039 has been discontinued.
说明： ACAT inhibitor
化学名： N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
纯度： ≥98% (HPLC)
生物活性 for YM 750
YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.
许可信息
Sold with the permission of Astellas Pharma Inc.
技术数据 for YM 750
| 分子量 | 452.63 |
| 公式 | C31H36N2O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 138046-43-2 |
| PubChem ID | 9911716 |
| InChI Key | FMLJREWZCZHGGW-UHFFFAOYSA-N |
| Smiles | O=C(NC5=C(C)C=C(C)C=C5C)N(C4CCCCCC4)CC3=CC2=C(C=C3)C1=CC=CC=C1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 750
参考文献 for YM 750
参考文献是支持产品生物活性的出版物。
Nagata et al (1995) N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 49 643 PMID: 7887979
Kamiya et al (2000) Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 48 817 PMID: 10866142
Miike et al (2008) Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 82 79 PMID: 18037448
关键词: YM 750, YM 750 supplier, Acyl-CoA:cholesterol, acyltransferase, ACAT, inhibitors, inhibits, transferase, YM750, Acyl-CoA:Cholesterol, Acyltransferase, 3039, Tocris Bioscience
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