Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewYM 976
说明： PDE4 inhibitor
化学名： 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
纯度： ≥98% (HPLC)
生物活性 for YM 976
Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
技术数据 for YM 976
| 分子量 | 313.79 |
| 公式 | C17H16ClN3O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 191219-80-4 |
| PubChem ID | 6604918 |
| InChI Key | MNHXYNNKDDXKNP-UHFFFAOYSA-N |
| Smiles | CCN1C(=O)N=C(C2=CC=CC(Cl)=C2)C2=C1N=C(CC)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 976
参考文献 for YM 976
参考文献是支持产品生物活性的出版物。
Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255 PMID: 10991987
Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142 PMID: 11504812
Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57 PMID: 12787831
按标靶查看相关产品
按产品操作查看相关产品
关键词: YM 976, YM 976 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, YM976, 1821, Tocris Bioscience
YM 976 的评论
目前没有该产品的评论。 Be the first to review YM 976 and earn rewards!
Have you used YM 976?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image