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Z-Guggulsterone

Cat. No. 3570 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)
化学名： (Z)-Pregna-4,17(20)-diene-3,16-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Z-Guggulsterone

Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

化合物库 for Z-Guggulsterone

Z-Guggulsterone is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Z-Guggulsterone

分子量 312.45
公式 C21H28O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 39025-23-5
PubChem ID 6450278
InChI Key WDXRGPWQVHZTQJ-OSJVMJFVSA-N
Smiles O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]/4(C)[C@]([H])3CC(C4=C/C)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Z-Guggulsterone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.25 20 温和加热
ethanol 3.12 10 温和加热

制备储备液 for Z-Guggulsterone

以下数据基于产品分子量 312.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 16 mL 80.01 mL 160.03 mL
1 mM 3.2 mL 16 mL 32.01 mL
2 mM 1.6 mL 8 mL 16 mL
10 mM 0.32 mL 1.6 mL 3.2 mL

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产品说明书 for Z-Guggulsterone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Z-Guggulsterone

参考文献是支持产品生物活性的出版物。

Singh et al (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 67 7439 PMID: 17671214

Xiao and Singh (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol.Cancer Ther. 7 171 PMID: 18202020

Meyer et al (2005) Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. J.Med.Chem. 48 6955 PMID: 16250653

If you know of a relevant reference for Z-Guggulsterone, please let us know.

按标靶查看相关产品

关键词: Z-Guggulsterone, Z-Guggulsterone supplier, Broad, spectrum, steroid, receptor, ligands, Nuclear, Receptors, progesterone, mineralocorticoid, glucocorticoid, Other, 3570, Tocris Bioscience

2 篇 Z-Guggulsterone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Z-Guggulsterone 的部分引用包括：

Michael S et al (2021) Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host Microbe 29 988-1001.e6 PMID: 34010595

Ng et al (2016) C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. Oncotarget 7 24005 PMID: 27006468

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