Zileuton

Cat. No. 3308 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： 5-LOX inhibitor; orally bioavailable

别名： ICI D2138

化学名： N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

纯度： ≥99% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Zileuton

Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB₄ synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (K_i = 66 - 98 μM). Ferroptosis inhibitor.

化合物库 for Zileuton

Zileuton is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Zileuton

分子量	236.29
公式	C₁₁H₁₂N₂O₂S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	111406-87-2
PubChem ID	60490
InChI Key	MWLSOWXNZPKENC-UHFFFAOYSA-N
Smiles	CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zileuton

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	23.63	100

制备储备液 for Zileuton

以下数据基于产品分子量 236.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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产品说明书 for Zileuton

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Zileuton

参考文献是支持产品生物活性的出版物。

McMillan et al (1992) Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 107 1042 PMID: 1334748

Malo et al (1994) The 5-lipoxygenase inhibitory activity of zil. in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 7 73 PMID: 8081074

Lu et al (2003) Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 31 1352 PMID: 14570767

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 269 PMID: 26794443

If you know of a relevant reference for Zileuton, please let us know.

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关键词: Zileuton, Zileuton supplier, Orally, active, 5-LOX, inhibitors, inhibits, Lipoxygenase, Oxygenases, Oxidases, ICID2138, ferroptosis, ICI, D2138, Ferroptosis, 3308, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Zileuton, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov