ZK 756326

Discontinued Product

2565 has been discontinued.

View all Chemokine CC Receptors products.
说明: Selective, non-peptide CCR8 agonist
化学名: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
纯度: ≥99% (HPLC)
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引用文献
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生物活性 for ZK 756326

ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

技术数据 for ZK 756326

分子量 429.38
公式 C21H28N2O3.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1780259-94-0
PubChem ID 56972201
InChI Key MPACCEKWFGWZHS-UHFFFAOYSA-N
Smiles OCCOCCN(CC3)CCN3CC1=CC=CC(OC2=CC=CC=C2)=C1.Cl.Cl

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献 for ZK 756326

参考文献是支持产品生物活性的出版物。

Haskell et al (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol.Pharmacol. 69 309 PMID: 16221874

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关键词: ZK 756326, ZK 756326 supplier, Selective, non-peptide, CCR8, agonists, CXCR, Chemokine, Receptors, ZK756326, CC, 2565, Tocris Bioscience

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