ZM 306416 hydrochloride

Name: ZM 306416 hydrochloride
Brand: Tocris Bioscience
SKU: 2499

Cat. No. 2499 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2499 has been discontinued.

View all VEGFR products.

说明： Inhibitor of VEGF receptor tyrosine kinase

化学名： 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (5)

文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for ZM 306416 hydrochloride

ZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC₅₀ values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

技术数据 for ZM 306416 hydrochloride

分子量	370.21
公式	C₁₆H₁₃N₃O₂FCl.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	196603-47-1
PubChem ID	21701577
InChI Key	SCUXIROMWPQVJO-UHFFFAOYSA-N
Smiles	Cl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ZM 306416 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ZM 306416 hydrochloride

参考文献是支持产品生物活性的出版物。

Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369 PMID: 10639280

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关键词: ZM 306416 hydrochloride, ZM 306416 hydrochloride supplier, inhibitors, inhibits, receptors, tyrosine, kinase, VEGFR, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, RTKs, ZM306416, hydrochloride, AstraZeneca, 2499, Tocris Bioscience

5 篇 ZM 306416 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZM 306416 hydrochloride 的部分引用包括：

Lee et al (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun 5 5583 PMID: 25428693

Zhang et al (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Dis Model Mech 9 1383 PMID: 27562099

Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528 PMID: 25788671

Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081

Marino et al (2018) Regulation of breast cancer induced bone disease by cancer-specific IKKβ. Oncotarget 9 16134 PMID: 29662632