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Zoledronic Acid

Cat. No. 6111 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent farnesyl diphosphate (FPP) synthase inhibitor
别名： Zometa
化学名： [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Zoledronic Acid

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

技术数据 for Zoledronic Acid

分子量 272.09
公式 C5H10N2O7P2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 118072-93-8
PubChem ID 68740
InChI Key XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zoledronic Acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1.1eq. NaOH 13.6 50
water 0.68 2.5

制备储备液 for Zoledronic Acid

以下数据基于产品分子量 272.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 7.35 mL 36.75 mL 73.51 mL
2.5 mM 1.47 mL 7.35 mL 14.7 mL
5 mM 0.74 mL 3.68 mL 7.35 mL
25 mM 0.15 mL 0.74 mL 1.47 mL

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产品说明书 for Zoledronic Acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Zoledronic Acid

参考文献是支持产品生物活性的出版物。

Schech et al (2013) Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 12 1356 PMID: 23619300

Tassone et al (2003) Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 88 1971 PMID: 12799645

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603

If you know of a relevant reference for Zoledronic Acid, please let us know.

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关键词: Zoledronic Acid, Zoledronic Acid supplier, bisphosphonate, NF-KB, NF-kappaB, NF-κB, signaling, inhibitors, inhibits, potent, FPP, synthase, farnesyl, diphosphate, Ras, Zometa, Other, Synthases/Synthetases, NF-kB/IkB, Cancer, Stem, Cells, GTPases, 6111, Tocris Bioscience

1 篇 Zoledronic Acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zoledronic Acid 的部分引用包括：

E et al (2020) GLP-2 administration in ovariectomized mice enhances collagen maturity but did not improve bone strength. Bone Rep 12 100251 PMID: 32071954

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