主页 / 药理学 / Ion Channels / Other Channel Modulators / Zonisamide

Zonisamide

Cat. No. 2625 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
别名： AD 810,CI 912
化学名： 1,2-Benzisoxazole-3-methanesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Zonisamide

Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

化合物库 for Zonisamide

Zonisamide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Zonisamide

分子量 212.22
公式 C8H8N2O3S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 68291-97-4
PubChem ID 5734
InChI Key UBQNRHZMVUUOMG-UHFFFAOYSA-N
Smiles NS(=O)(=O)CC1=NOC2=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zonisamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 2.12 10
DMSO 21.22 100

制备储备液 for Zonisamide

以下数据基于产品分子量 212.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.56 mL 47.12 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Zonisamide

参考文献是支持产品生物活性的出版物。

Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 25 1107 PMID: 11055748

Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463

Gluck et al (2004) Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218

Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467

If you know of a relevant reference for Zonisamide, please let us know.

按标靶查看相关产品

关键词: Zonisamide, Zonisamide supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, AD, 810, CI, 912, Other, Channel, Modulators, Miscellaneous, Glutamate, GABAB, Receptors, 2625, Tocris Bioscience

篇 Zonisamide 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Zonisamide 的引用文献。 您是否知道使用了 Tocris Zonisamide 的优秀论文？ 请告知我们.

Zonisamide 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used Zonisamide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities.
By Anonymous on 02/27/2019
种属： Human

Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.

review image