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Submit ReviewZonisamide
说明： Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
别名： AD 810,CI 912
化学名： 1,2-Benzisoxazole-3-methanesulfonamide
纯度： ≥99% (HPLC)
生物活性 for Zonisamide
Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
化合物库 for Zonisamide
Zonisamide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Zonisamide
| 分子量 | 212.22 |
| 公式 | C8H8N2O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 68291-97-4 |
| PubChem ID | 5734 |
| InChI Key | UBQNRHZMVUUOMG-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)CC1=NOC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Zonisamide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 2.12 | 10 | |
| DMSO | 21.22 | 100 |
制备储备液 for Zonisamide
以下数据基于产品分子量 212.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.71 mL | 23.56 mL | 47.12 mL |
| 5 mM | 0.94 mL | 4.71 mL | 9.42 mL |
| 10 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
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产品说明书 for Zonisamide
参考文献 for Zonisamide
参考文献是支持产品生物活性的出版物。
Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 25 1107 PMID: 11055748
Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463
Gluck et al (2004) Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218
Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467
If you know of a relevant reference for Zonisamide, please let us know.
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关键词: Zonisamide, Zonisamide supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, AD, 810, CI, 912, Other, Channel, Modulators, Miscellaneous, Glutamate, GABAB, Receptors, 2625, Tocris Bioscience
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Zonisamide 的评论
平均评分: 5 (Based on 1 Review.)
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Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities.
By
Anonymous on 02/27/2019
种属： Human
Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.
