Zosuquidar trihydrochloride

Cat. No. 5456 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： High affinity P-gp inhibitor

别名： LY 335979

化学名： (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

纯度： ≥97% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Zosuquidar trihydrochloride

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (K_d = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

化合物库 for Zosuquidar trihydrochloride

Zosuquidar trihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Zosuquidar trihydrochloride

分子量	636.99
公式	C₃₂H₃₁F₂N₃O₂.3HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	167465-36-3
PubChem ID	153997
InChI Key	ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Smiles	F[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zosuquidar trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.85	50

制备储备液 for Zosuquidar trihydrochloride

以下数据基于产品分子量 636.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.14 mL	15.7 mL	31.4 mL
2.5 mM	0.63 mL	3.14 mL	6.28 mL
5 mM	0.31 mL	1.57 mL	3.14 mL
25 mM	0.06 mL	0.31 mL	0.63 mL

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产品说明书 for Zosuquidar trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Zosuquidar trihydrochloride

参考文献是支持产品生物活性的出版物。

Dantzig et al (1999) Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 290 854 PMID: 10411602

Dantzig et al (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56 4171 PMID: 8797588

If you know of a relevant reference for Zosuquidar trihydrochloride, please let us know.

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关键词: Zosuquidar trihydrochloride, Zosuquidar trihydrochloride supplier, LY335979, RS33295198, high, affinity, p-glycoprotein, p-gp, inhibitors, inhibits, multidrug, transporters, resistance, LY, 335979, Multidrug, Transporters, 5456, Tocris Bioscience

3 篇 Zosuquidar trihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zosuquidar trihydrochloride 的部分引用包括：

Troy et al (2021) A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. JCI Insight 6 PMID: 33476303

Dalia et al (2022) Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. ACS Chem Biol 17 2801-2816 PMID: 36084291

Terrance G et al (2019) Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents. ACS Pharmacol Transl Sci 2 402-413 PMID: 32259073

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