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Submit ReviewZotepine
说明： 5-HT2A antagonist; also D2 and H1 antagonist; atypical antipsychotic
化学名： 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
纯度： ≥99% (HPLC)
生物活性 for Zotepine
5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo.
技术数据 for Zotepine
| 分子量 | 331.86 |
| 公式 | C18H18ClNOS |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 26615-21-4 |
| PubChem ID | 5736 |
| InChI Key | HDOZVRUNCMBHFH-UHFFFAOYSA-N |
| Smiles | ClC3=CC=C2SC1=CC=CC=C1C=C(OCCN(C)C)C2=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Zotepine
参考文献 for Zotepine
参考文献是支持产品生物活性的出版物。
Herrick-Davis et al (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 226 PMID: 10991983
Yamamura et al (2009) Effects of zotepine on extracellular levels of monamine, GABA and glutamate in rat prefrontal cortex. Br.J.Pharmacol. 157 656 PMID: 19371334
Shobo et al (2010) Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of NE reuptake. J.Pharmacol.Exp.Ther. 333 772 PMID: 20223878
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关键词: Zotepine, Zotepine supplier, 5-HT2A, serotonergic, dopamine, dopaminergic, D2, histamine, H1, receptors, antagonists, 5-HT2A/D2, atypical, antipsychotic, Receptors, Histamine, 3996, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.