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Submit ReviewZQ 16
说明： Selective GPR84 agonist
化学名： 2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
纯度： ≥98% (HPLC)
生物活性 for ZQ 16
ZQ 16 is a selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.
技术数据 for ZQ 16
| 分子量 | 228.31 |
| 公式 | C10H16N2O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 376616-73-8 |
| PubChem ID | 1912564 |
| InChI Key | UYXOAKRMLQKLQX-UHFFFAOYSA-N |
| Smiles | CCCCCCSC1=NC(O)=CC(N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ZQ 16
参考文献 for ZQ 16
参考文献是支持产品生物活性的出版物。
Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID: 27326330
Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID: 26962172
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关键词: ZQ 16, ZQ 16 supplier, ZQ16, selective, medium, chain, free, fatty, acid, receptor, GPR84, agonists, agonism, Free, Fatty, Acid, Receptors, 6001, Tocris Bioscience
1 篇 ZQ 16 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ZQ 16 的部分引用包括：
Sundqvist (2018) Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta 1865 695 PMID: 29477577
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