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Submit ReviewSB 203580
Description: Selective inhibitor of p38 MAPK
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Purity: ≥98% (HPLC)
Biological Activity for SB 203580
SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.
Water-soluble Salt also available.
Compound Libraries for SB 203580
SB 203580 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for SB 203580
| M. Wt | 377.44 |
| Formula | C21H16FN3OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 152121-47-6 |
| PubChem ID | 176155 |
| InChI Key | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| Smiles | CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 203580
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.44 | 25 |
Preparing Stock Solutions for SB 203580
The following data is based on the product molecular weight 377.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.6 mL | 52.99 mL | 105.98 mL |
| 1.25 mM | 2.12 mL | 10.6 mL | 21.2 mL |
| 2.5 mM | 1.06 mL | 5.3 mL | 10.6 mL |
| 12.5 mM | 0.21 mL | 1.06 mL | 2.12 mL |
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Product Datasheets for SB 203580
References for SB 203580
References are publications that support the biological activity of the product.
Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766 PMID: 9786874
Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95 PMID: 10998351
Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586 PMID: 8636072
Sato et al (2008) Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J.Neurosci.Res. 86 2179 PMID: 18338804
Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282 PMID: 24172903
Jiang et al (2021) Effects of signaling pathway inhibitors on hematopoietic stem cells. Mol.Med.Rep. 23 9 PMID: 33179097
If you know of a relevant reference for SB 203580, please let us know.
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Keywords: SB 203580, SB 203580 supplier, Selective, inhibitors, inhibits, p38, MAPK, Mitogen-Activated, Protein, Kinases, Signaling, Signalling, SB203580, GlaxoSmithKline, GSK, hematopoietic, haematopoietic, stem, cells, HSC, Stem, Cell, Proliferation, Other, Antivirals, Hematopoietic, Cells, 1202, Tocris Bioscience
106 Citations for SB 203580
Citations are publications that use Tocris products. Selected citations for SB 203580 include:
Singh et al (2018) Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol 37 521 PMID: 28629242
Wan et al (2018) Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction. Int J Mol Med 41 1939 PMID: 29393413
Liu et al (2015) Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. Biogerontology 5 79 PMID: 25999956
Davis et al (2015) Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence. Exp Hematol Oncol 16 43 PMID: 25214013
Koerber et al (2015) Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma. Mol Vis 4 21 PMID: 26251761
Brosig et al (2015) Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Immunol Cell Biol 21 1000 PMID: 26330750
Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. Int J Mol Med 93 461 PMID: 25582338
Aziz et al (2015) MFG-E8 inhibits neutrophil migration through αvβ3-integrin-dependent MAP kinase activation. Elife 36 18 PMID: 25936372
Zebrowski et al (2015) Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. Mol Vis 4 PMID: 26247711
Wei et al (2014) Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling. Am J Physiol Heart Circ Physiol 307 H1643 PMID: 25260613
Heckler et al (2014) ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamox. resistance in ER+ breast cancer. FEBS J 281 2431 PMID: 24684682
Pera et al (2010) Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Exp Cell Res 11 48 PMID: 20429916
Novoyatleva et al (2010) TWEAK is a positive regulator of cardiomyocyte proliferation. Toxins (Basel) 85 681 PMID: 19887380
Andersson et al (2018) Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight 3 PMID: 30333314
Simões-Sousa et al (2018) The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α. Cell Rep 25 749 PMID: 30332653
Kang et al (2018) Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Rep 25 2563 PMID: 30485820
Xing et al (2018) Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J 59 1131 PMID: 30328329
Lin et al (2018) Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells. Cancer Manag Res 10 4237 PMID: 30323679
Kleiner et al (2018) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis 24 647 PMID: 30310263
Guo et al (2018) Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Res Ther 9 281 PMID: 30359318
Yang et al (2016) The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Cardiorenal Med 7 11385 PMID: 27150562
Ju et al (2012) Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis. Diabetologia 18 992 PMID: 22451267
Cai et al (2012) Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. J Cell Mol Med 531 125 PMID: 23123784
Chen et al (2012) Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells. PLoS One 16 1447 PMID: 21854542
Hecker et al (2011) Reversible differentiation of myofibroblasts by MyoD. J Neurosci 317 1914 PMID: 21440539
Sethi et al (2011) Role of TGFβ/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. PLoS One 52 5251 PMID: 21642622
Kim et al (2011) Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Mol Cancer 15 211 PMID: 21994479
Kovac et al (2011) Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Biol Chem 8 139 PMID: 21995440
Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213
Yang et al (2015) 1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients. PLoS One 10 e0120515 PMID: 25905635
Tang et al (2015) P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance. J Immunol 195 1191 PMID: 26116509
Wan et al (2014) Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J 28 3456 PMID: 24736410
Yu et al (2014) Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS One 9 e112989 PMID: 25398056
Kim et al (2014) AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2. J Ginseng Res 38 16 PMID: 24558305
Kim et al (2014) Decrease of PKB/Akt Phosphorylation is Partially Mediated by SAPK/JNK Activation in Serum-free L6 Myoblasts Starved with Low Glucose. J Phys Ther Sci 26 1757 PMID: 25435694
Gonsalves et al (2014) Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α. Am J Hematol 89 273 PMID: 24227191
Bae et al (2014) Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol 306 C918 PMID: 24627558
Caldwell et al (2014) Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev 28 2120 PMID: 25274725
Choi et al (2013) EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity. PLoS One 4 2383 PMID: 24280371
Jensen et al (2013) An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. J Neurosci 13 67 PMID: 23332156
Enomoto et al (2013) Transcriptional regulation of an Ins-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15. Mol Med 8 e83183 PMID: 24358263
Sethi et al (2013) Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. J Neuroinflammation 113 117 PMID: 23748100
Kang et al (2011) MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways. J Immunol 187 222 PMID: 21622856
Suh et al (2011) Induction of steroid sulfatase expression by tumor necrosis factor-α through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells. Exp Mol Med 43 646 PMID: 21904110
Kim et al (2019) LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS One 14 e0210248 PMID: 30645642
Al-Taei et al (2017) Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology 6 e1268308 PMID: 28344879
Yang et al (2017) Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell 169 243 PMID: 28388409
Fish et al (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development 144 2428 PMID: 28536097
green and Thayer et al (2019) HIV gp120 upregulates tonic inhibition through α5-containing GABAARs. Neuropharmacology 149 161 PMID: 30797029
Cervigni et al (2015) JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65. J Cell Sci 128 2249 PMID: 25948586
Liang et al (2014) δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Exp Eye Res 171 5417 PMID: 25052197
Bernet et al (2014) p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Korean J Physiol Pharmacol 20 265 PMID: 24531379
Beermann et al (2014) Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. Respir Res 9 e107481 PMID: 25243776
Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126
Kim et al (2013) Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem 288 22693 PMID: 23754277
Katholnig et al (2013) p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin. J Immunol 190 1519 PMID: 23315073
Makhortova et al (2011) A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol 7 544 PMID: 21685895
Isfort et al (2011) Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. J Biol Chem 286 44776 PMID: 22057273
Tsai et al (2011) Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr 141 2119 PMID: 22031657
Zhou and Too (2011) Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth. Nat Med 6 e21680 PMID: 21738764
Steubesand et al (2009) The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol 10 36 PMID: 19523197
Yeligar et al (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183 5964 PMID: 19828633
Sanit et al (2019) Combination of MetF. and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats. Exp Ther Med 18 1701 PMID: 31410128
Messerschmidt et al (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis 25 329 PMID: 31341381
Moniruzzaman et al (2019) Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. Int J Mol Sci 20 PMID: 31311100
Neamatallah et al (2019) Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function. Int J Mol Sci 20 PMID: 31336892
Ulzii et al (2019) Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes. Int J Mol Sci 20 PMID: 31284553
Wu (2017) TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells. Arch Biochem Biophys 622 26 PMID: 28442401
Han (2017) Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res 1663 132 PMID: 28322749
Li et al (2015) MAPK signaling downstream to TLR4 contributes to PacT.-induced peripheral neuropathy. Brain Behav.Immun. 49 255 PMID: 26065826
Siegl (2012) Using the one-lung method to link p38 to pro-inflammatory gene expression during overventilation in C57BL/6 and BALB/c mice. PLoS One 7 e41464 PMID: 22848503
Sutcliffe et al (2009) Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1. Br J Pharmacol 157 436 PMID: 19371341
Davis and Kipling (2009) Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts. Biogerontology 10 253 PMID: 18830681
Doulatov et al (2009) PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev 23 2076 PMID: 19723763
Zhou et al (2019) Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep 27 3844 PMID: 31242418
Suk et al (2013) A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells. Evid Based Complement Alternat Med 2013 658370 PMID: 24222778
Marlow et al (2013) A novel model of dormancy for bone metastatic breast cancer cells. Cancer Res 73 6886 PMID: 24145351
Lang et al (2013) Effect of thiorid. on erythrocytes. Toxins (Basel) 5 1918 PMID: 24152992
Yi et al (2012) TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation. PLoS One 7 e30404 PMID: 22347375
Santos et al (2012) Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. PLoS One 7 e33468 PMID: 22432027
Rahman et al (2016) 18α-glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis. Biochemical Pharmacology 117 97 PMID: 27520483
Chang et al (2016) Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells. PLoS One 11 e0165715 PMID: 27802323
Hollborn et al (2015) Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Oncotarget 21 360 PMID: 25878490
Koeglsperger et al (2013) Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia 61 985 PMID: 23536313
Kook et al (2013) Fibroblast growth factor-4 enhances proliferation of mouse embryonic stem cells via activation of c-Jun signaling. PLoS One 8 e71641 PMID: 23967228
Gardoni et al (2012) The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway. J Cell Sci 125 1401 PMID: 22328515
Trendelenburg et al (2012) TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of AVNA. Skelet Muscle 2 3 PMID: 22313861
Meotti et al (2012) Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways. Br J Pharmacol 166 1127 PMID: 22220695
Khuituan et al (2012) Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab 302 E903 PMID: 22275752
Zhou et al (2010) miR-155 and its star-form partner miR-155* cooperatively regulate type I IF. production by human plasmacytoid dendritic cells. Blood 116 5885 PMID: 20852130
Yoo et al (2010) Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. Korean J Physiol Pharmacol 14 139 PMID: 20631885
Yun et al (2005) Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. Nat Commun 280 9963 PMID: 15640157
Gallagher et al (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. Neurosci Lett 24 4859 PMID: 15152046
Kauppinen et al (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A 103 7136 PMID: 16627622
Sunters et al (2006) PacT.-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res 66 212 PMID: 16397234
Tyszkiewicz and Yan (2005) beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons. J Neurophysiol 93 3102 PMID: 15659527
Zhou et al (2007) Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Invest Ophthalmol Vis Sci 72 765 PMID: 17714751
Alao et al (2006) Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Steroids 5 40 PMID: 17018141
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Aiston et al (2006) The role of protein kinase B/Akt in Ins-induced inactivation of phosphorylase in rat hepatocytes. Cardiovasc Res 49 174 PMID: 16341839
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Reviews for SB 203580
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Filter by:
Combinatorial treatments.
By
MARINA KOUTSIOUMPA on 10/18/2022
Assay Type: In Vitro
Species: Human
Combinatorial treatments of the p38 MAPK inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro. The product is highly recommended.
The role of p38 MAPK signaling in genotoxics-induced stress..
By
MARINA KOUTSIOUMPA on 06/10/2021
Assay Type: In Vitro
Species: Human
SB 203580 was dissolved in DMSO and used at a final concentration of 1, 3 or 10 µM in human cancer cell lines, followed by treatment with genotoxics.
Used for Migration assays.
By
Anonymous on 07/01/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: A549 or MDAMB231
All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
The role of p38 MAPK signaling in LPA induced pro-inflammatory phenotype in microglia cells.
By
Joanna Plastira on 06/08/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary murine microglia cells
The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of SB239063 (10µM) or SB203580 (10µM). A series of assays were performed. p38 MAPK inhibition totally decreased the expression of 4 pro-inflammatory transcription factors (here presented: pp65). Both inhibitors worked nicely and the results were consistent.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SB 203580
