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Submit ReviewMMK 1
Description: Potent and selective FPR2 agonist
Purity: ≥95% (HPLC)
Biological Activity for MMK 1
MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
DMSO is not recommended as a solvent for this peptide.
Technical Data for MMK 1
| M. Wt | 1610.97 |
| Formula | C75H123N19O18S |
| Sequence | LESIFRSLLFRVM |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 271246-66-3 |
| PubChem ID | 25074458 |
| InChI Key | PWBQRCXCXXGUGY-AJOXZCOLSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MMK 1
References for MMK 1
References are publications that support the biological activity of the product.
Hu et al (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J.Leukoc.Biol. 70 155 PMID: 11435499
Klein et al (1998) Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nature Biotech. 16 1334
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Keywords: MMK 1, MMK 1 supplier, Potent, selective, FPR2, agonists, FPRL, Formyl, Peptide, Receptors, MMK1, 3537, Tocris Bioscience
2 Citations for MMK 1
Citations are publications that use Tocris products. Selected citations for MMK 1 include:
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962
Reviews for MMK 1
Average Rating: 4 (Based on 1 Review.)
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Following protocol.
By
Christopher Durrant on 01/09/2020
Assay Type: Ex Vivo
Species: Human
looking at human formyl peptide receptor
Followed publication