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Submit ReviewRepaglinide
Description: Kir6 (KATP) channel blocker
Alternative Names: AG-EE 623ZW
Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
Purity: ≥99% (HPLC)
Biological Activity for Repaglinide
Repaglinide is a Kir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.
Compound Libraries for Repaglinide
Repaglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Repaglinide
| M. Wt | 452.59 |
| Formula | C27H36N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 135062-02-1 |
| PubChem ID | 65981 |
| InChI Key | FAEKWTJYAYMJKF-QHCPKHFHSA-N |
| Smiles | O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Repaglinide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.26 | 100 | |
| ethanol | 45.26 | 100 |
Preparing Stock Solutions for Repaglinide
The following data is based on the product molecular weight 452.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for Repaglinide
References for Repaglinide
References are publications that support the biological activity of the product.
Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repagl. in rats and dogs. Br.J.Pharmacol. 121 1597 PMID: 9283692
Hansen et al (2005) Kir6.2-dependent high-affinity repagl. binding to β-cell KATP channels. Br.J.Pharmacol. 144 551 PMID: 15678092
If you know of a relevant reference for Repaglinide, please let us know.
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Keywords: Repaglinide, Repaglinide supplier, K+, channel, pore, blockers, KATP, Blocks, SUR1, KIR6, Kir6.2, sulphonylurea, receptor, inward, rectifier, AG-EE, 623ZW, Inward, Potassium, Channels, 3805, Tocris Bioscience
Citations for Repaglinide
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