Inward Rectifier Potassium (Kir) Channels
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.
Inward Rectifier Potassium (Kir) Channel Activators |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 0964 | Diazoxide |
| Kir6 (KATP) channel opener | |
| 1378 | Levcromakalim |
| Kir6 (KATP) channel opener; active enantiomer of Cromakalim | |
| 0583 | Minoxidil |
| Kir6 channel (KATP) opener | |
| 5380 | ML 297 |
| Selective Kir3.1/3.2 (GIRK1/2) channel activator | |
| 2580 | Tenidap |
| Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor | |
| 7057 | VU 0071063 |
| Selective activator of SUR1 Kir6.2 channels | |
| 2076 | Y-26763 |
| Kir6 (KATP) channel opener | |
Inward Rectifier Potassium (Kir) Channel Blockers |
|
| Cat. No. | Product Name / Activity |
| 6086 | AMP PNP |
| Kir6 blocker; non-hydrolyzable AMP analog | |
| 1513 | CGP 7930 |
| Blocks G protein-coupled inwardly rectifying K+ (GIRK) channels | |
| 0911 | Glibenclamide |
| Kir6 (KATP) channel blocker | |
| 4549 | ML 133 hydrochloride |
| Kir2 channel blocker | |
| 6889 | ML 418 |
| Kir 7.1 inhibitor; also inhibits Kir 6.2 | |
| 4231 | Nateglinide |
| Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels | |
| 2095 | PNU 37883 hydrochloride |
| Vascular Kir6 (KATP) channel blocker | |
| 3805 | Repaglinide |
| Kir6 (KATP) channel blocker | |
| 0925 | SCH 23390 hydrochloride |
| Kir3 channel blocker; also potent dopamine D1-like antagonist and 5-HT2C agonist | |
| 3948 | Terfenadine |
| KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist | |
| 1316 | Tertiapin-Q |
| Selective blocker of inward-rectifier K+ channels | |
| 6877 | VU 0134992 |
| Kir4.1 blocker | |
| 8151 | VU 0542270 New |
| Selective inhibitor of Kir6.1 KATP channels | |
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
External sources of pharmacological information for Inward Rectifier Potassium (Kir) Channels :
Inward-Rectifier Potassium Channel Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| KIR1.1 (ROMK1) (ATP-sensitive) | Human | KCNJ1 | NM_000220 | P48048 |
| Mouse | Kcnj1 | NM_019659 | O88335 | |
| Rat | Kcnj1 | NM_017023 | P35560 | |
| KIR2.1 (IRK1) | Human | KCNJ2 | NM_000891 | P63252 |
| Mouse | Kcnj2 | NM_008425 | P35561 | |
| Rat | Kcnj2 | NM_017296 | Q64273 | |
| KIR2.2(IRK2) | Human | KCNJ12 | NM_021012 | Q14500 |
| Mouse | Kcnj12 | NM_010603 | P52187 | |
| Rat | Kcnj12 | NM_053981 | P52188 | |
| KIR2.3 (IRK3) | Human | KCNJ4 | NM_004981 | P48050 |
| Mouse | Kcnj4 | NM_008427 | P52189 | |
| Rat | Kcnj4 | NM_053870 | P52190 | |
| KIR2.4 (IRK4) | Human | KCNJ14 | NM_013348 | Q9UNX9 |
| Mouse | Kcnj14 | NM_145963 | Q8JZN3 | |
| Rat | Kcnj14 | NM_170718 | O70596 | |
| KIR3.1 (GIRK1) | Human | KCNJ3 | NM_002239 | P48549 |
| Mouse | Kcnj3 | NM_008426 | P63250 | |
| Rat | Kcnj3 | NM_031610 | P63251 | |
| KIR3.2 (GIRK2) | Human | KCNJ6 | NM_002240 | P48051 |
| Mouse | Kcnj6 | NM_001025590 | P48542 | |
| Rat | Kcnj6 | NM_013192 | P48550 | |
| KIR3.3 (GIRK3) | Human | KCNJ9 | NM_004983 | Q92806 |
| Mouse | Kcnj9 | NM_008429 | P48543 | |
| Rat | Kcnj9 | NM_053834 | Q63511 | |
| KIR3.4 (GIRK4) | Human | KCNJ5 | NM_000890 | P48544 |
| Mouse | Kcnj5 | NM_010605 | P48545 | |
| Rat | Kcnj5 | NM_017297 | P48548 | |
| KIR4.1 (KIR1.2) | Human | KCNJ10 | NM_002241 | P78508 |
| Mouse | Kcnj10 | NM_001039484 | Q9JM63 | |
| Rat | Kcnj10 | NM_031602 | P49655 | |
| KIR4.2 (KIR1.3) | Human | KCNJ15 | NM_002243 | Q99712 |
| Mouse | Kcnj15 | NM_019664 | O88932 | |
| Rat | Kcnj15 | NM_133321 | Q91ZF1 | |
| KIR5.1 | Human | KCNJ16 | NM_018658 | Q9NPI9 |
| Mouse | Kcnj16 | NM_010604 | Q9Z307 | |
| Rat | Kcnj16 | NM_053314 | P52191 | |
| KIR6.1 (KATP) | Human | KCNJ8 | NM_004982 | Q15842 |
| Mouse | Kcnj8 | NM_008428 | P97794 | |
| Rat | Kcnj8 | NM_017099 | Q63664 | |
| KIR6.2 (KATP) | Human | KCNJ11 | NM_000525 | Q14654 |
| Mouse | Kcnj11 | NM_010602 | Q61743 | |
| Rat | Kcnj11 | NM_031358 | P70673 | |
| KIR7.1 | Human | KCNJ13 | NM_002242 | O60928 |
| Mouse | Kcnj13 | NM_008428 | P97794 | |
| Rat | Kcnj13 | NM_053608 | O70617 |