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Description: Potent PDGFR and VEGFR inhibitor
Alternative Names: Palladia
Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for Toceranib
Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer.
Technical Data for Toceranib
| M. Wt | 396.46 |
| Formula | C22H25FN4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 356068-94-5 |
| PubChem ID | 5329106 |
| InChI Key | SRSGVKWWVXWSJT-ATVHPVEESA-N |
| Smiles | O=C2NC1=CC=C(F)C=C1/C2=C/C3=C(C)C(C(NCCN4CCCC4)=O)=C(C)N3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Toceranib
References for Toceranib
References are publications that support the biological activity of the product.
Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585 PMID: 12091352
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Keywords: Toceranib, Toceranib supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Palladia, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 3909, Tocris Bioscience
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.