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Submit ReviewTC-SP 14
Discontinued Product
4363 has been discontinued.
View all Sphingosine-1-Phosphate Receptors products.
Description: Potent S1P1 receptor agonist
Chemical Name: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for TC-SP 14
TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.
Technical Data for TC-SP 14
| M. Wt | 450.5 |
| Formula | C25H20F2N2O2S |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1257093-40-5 |
| PubChem ID | 51346934 |
| InChI Key | GVXGVDIXINMAAL-UHFFFAOYSA-N |
| Smiles | FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC-SP 14
References for TC-SP 14
References are publications that support the biological activity of the product.
Lanman et al (2011) Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1). ACS Med.Chem.Lett. 2 102
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Keywords: TC-SP 14, TC-SP 14 supplier, TCSP14, Potent, sphingosine, 1, phosphate, receptor, S1P1, agonist, delayed, type, hypersensitivity, immune, response, orally, bioavailable, Sphingosine-1-phosphate, Receptors, 4363, Tocris Bioscience
Citations for TC-SP 14
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Currently there are no citations for TC-SP 14.
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