Sphingosine-1-Phosphate Receptors
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
Sphingosine-1-Phosphate Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5766 | A 971432 |
| Potent and selective S1P5 agonist | |
| 4543 | CS 2100 |
| Selective S1P1 agonist | |
| 4677 | CYM 50260 |
| Potent and selective S1P4 agonist | |
| 4678 | CYM 50308 |
| Potent and selective S1P4 agonist | |
| 3601 | CYM 5442 hydrochloride |
| Selective S1P1 receptor agonist | |
| 5418 | CYM 5520 |
| Selective S1P2 allosteric agonist | |
| 4897 | CYM 5541 |
| Selective S1P3 receptor allosteric agonist | |
| 6176 | FTY 720 |
| Potent S1P receptor agonist; also immunosuppressant | |
| 6709 | GSK 2018682 |
| S1P1 and S1P5 agonist | |
| 7663 | Ozanimod |
| Potent and selective S1P1 and S1P5 agonist | |
| 4289 | RP 001 hydrochloride |
| Potent S1P1 agonist | |
| 2284 | SEW 2871 |
| Cell-permeable, selective S1P1 receptor agonist | |
| 1370 | Sphingosine-1-phosphate |
| Endogenous agonist at S1P1-5 | |
Sphingosine-1-Phosphate Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 4679 | CYM 50358 hydrochloride |
| Potent and selective S1P4 antagonist | |
| 5833 | Ex 26 |
| Potent and selective S1P1 receptor antagonist | |
| 2392 | JTE 013 |
| S1P2 receptor antagonist | |
| 6498 | TASP 0277308 |
| Potent and selective S1P1 receptor antagonist; inhibits angiogenesis | |
| 5328 | TY 52156 |
| S1P3 receptor antagonist | |
| 4195 | VPC 23019 |
| S1P1 and S1P3 antagonist | |
| 3602 | W146 |
| Potent and selective S1P1 receptor antagonist | |
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes.
Both the S1P1 and S1P3 receptors are expressed ubiquitously. The S1P2 receptor is expressed postnatally in the brain, heart, lung, stomach, intestine and adrenal gland. The expression of S1P4 and S1P5 is less widespread, and confined to lymphoid tissue and white matter respectively.
S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes; and Gq modulates a range of cellular effector functions.
External sources of pharmacological information for Sphingosine-1-Phosphate Receptors :
Sphingosine-1-Phosphate Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| S1P1 | Human | S1PR1 | NM_001400 | P21453 |
| Mouse | S1pr1 | NM_007901 | O08530 | |
| Rat | S1pr1 | NM_017301 | P48303 | |
| S1P2 | Human | S1PR2 | NM_004230 | O95136 |
| Mouse | S1pr2 | NM_010333 | P52592 | |
| Rat | S1pr2 | NM_017192 | P47752 | |
| S1P3 | Human | S1PR3 | NM_005226 | Q99500 |
| Mouse | S1pr3 | NM_010101 | Q9Z0U9 | |
| Rat | S1pr3 | XM_225216 | Q9QZG4 | |
| S1P4 | Human | S1PR4 | NM_003775 | O95977 |
| Mouse | S1pr4 | NM_010102 | Q9Z0L1 | |
| Rat | S1pr4 | NM_001108075 | NP_001101545 | |
| S1P5 | Human | S1PR5 | NM_030760 | Q9H228 |
| Mouse | S1pr5 | NM_053190 | Q91X56 | |
| Rat | S1pr5 | NM_021775 | Q9JKM5 |