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Submit ReviewBorrelidin
Description: Antiangiogenic; inhibits threonyl-tRNA synthetase
Chemical Name: (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for Borrelidin
Borrelidin is an antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.
Technical Data for Borrelidin
| M. Wt | 489.64 |
| Formula | C28H43NO6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 7184-60-3 |
| PubChem ID | 5357974 |
| InChI Key | OJCKRNPLOZHAOU-SLNPHPKOSA-N |
| Smiles | O[C@@H](C1)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)\C(C#N)=C/C=C/C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])OC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Borrelidin
References for Borrelidin
References are publications that support the biological activity of the product.
Wakabayashi et al (1997) Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J.Antibiot.(Tokyo). 50 671 PMID: 9315080
Kawamura et al (2003) Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. J.Antibiot.(Tokyo). 56 709 PMID: 14563161
Woolard et al (2011) Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms. Chem.Sci. 273 PMID: 22822423
Sidhu et al (2015) Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med.Chem.Lett. 6 1122 PMID: 26617965
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Keywords: Borrelidin, Borrelidin supplier, antibacterials, antibiotics, threonyl-tRNA, synthetase, ThrRS, antiangiogenics, capillary, capillaries, formation, inhibitors, inhibits, Other, Synthases/Synthetases, Antiangiogenics, Antibiotics, 4706, Tocris Bioscience
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