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Submit ReviewEG 00229
Discontinued Product
This product has been withdrawn from sale and is superseded by EG 00229 trifluoroacetate (Cat. No. 6986)
Description: Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine
Purity: ≥98% (HPLC)
Biological Activity for EG 00229
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.
Technical Data for EG 00229
| M. Wt | 497.57 |
| Formula | C17H19N7O5S3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1018927-63-3 |
| PubChem ID | 44631827 |
| InChI Key | ZWWMEDURALZMEV-NSHDSACASA-N |
| Smiles | O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EG 00229
References for EG 00229
References are publications that support the biological activity of the product.
Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215 PMID: 20151671
Grun et al (2016) VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 35 4379 PMID: 26804163
Miyauchi et al (2016) Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression. Oncotarget. 7 9801 PMID: 26755653
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Keywords: EG 00229, EG 00229 supplier, EG00229, antagonists, VEGFA, receptors, neuropilin, nrp1, taxol, increases, chemo, sensitivity, Vascular, endothelial, growth, factor, VEGFR, 4931, Tocris Bioscience
1 Citation for EG 00229
Citations are publications that use Tocris products. Selected citations for EG 00229 include:
Nissen et al (2013) Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J.Neurochem. 127 394 PMID: 24033337
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for EG 00229
