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Perhexiline maleate

Cat. No. 5166 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Description: Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Perhexiline maleate

Perhexiline maleate is a carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.

Compound Libraries for Perhexiline maleate

Perhexiline maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Perhexiline maleate

M. Wt 393.56
Formula C19H35N.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 6724-53-4
PubChem ID 5284439
InChI Key JDZOTSLZMQDFLG-BTJKTKAUSA-N
Smiles OC(\C=C/C(O)=O)=O.C1(CC(C3CCCCC3)C2CCCCC2)NCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Perhexiline maleate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.36 100
ethanol 7.87 20

Preparing Stock Solutions for Perhexiline maleate

The following data is based on the product molecular weight 393.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.7 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for Perhexiline maleate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Perhexiline maleate

References are publications that support the biological activity of the product.

Kennedy et al (1996) Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiod. Biochem.Pharmacol. 52 273 PMID: 8694852

Unger et al (2005) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium. J.Cardiovasc.Pharmacol. 46 849 PMID: 16306812

Yin et al (2013) Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome. J.Mol.Cell.Cardiol. 55 27 PMID: 23277191

If you know of a relevant reference for Perhexiline maleate, please let us know.

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Keywords: Perhexiline maleate, Perhexiline maleate supplier, Carnitine, palmitoyltransferase-1/2, CPT1, CPT2, antianginal, cardiac, inhibits, inhibitors, Other, Transferases, 5166, Tocris Bioscience

1 Citation for Perhexiline maleate

Citations are publications that use Tocris products. Selected citations for Perhexiline maleate include:

Louis-Philippe et al (2020) Microglial metabolic flexibility supports immune surveillance of the brain parenchyma. Nat Commun 11 1559 PMID: 32214088

Do you know of a great paper that uses Perhexiline maleate from Tocris? Please let us know.

Reviews for Perhexiline maleate

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CPT1 antagonism on acute brain slices.
By Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Used as a second way to block CPT1 (etomoxir was the other blocker used). Both had the same effect, confirming the involvement of CPT1 in our assay.

30 minute pre-incubation, rapid effect