IP7e

Cat. No. 5699 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent Nurr1 activator

Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (1)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for IP7e

IP7e is a potent Nurr1 activator (EC₅₀ = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.

Compound Libraries for IP7e

IP7e is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for IP7e

M. Wt	390.43
Formula	C₂₃H₂₂N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	500164-74-9
PubChem ID	9908426
InChI Key	YCAACZFPADQMAR-UHFFFAOYSA-N
Smiles	CN1C(C2=CC=C(COCCOC)C=C2)=CC3=C(C(C4=CC=CC=C4)=NO3)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IP7e

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.04	100
	ethanol	7.81	20 with gentle warming

Preparing Stock Solutions for IP7e

The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Product Datasheets for IP7e

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for IP7e

References are publications that support the biological activity of the product.

Hintermann et al (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg.Med.Chem.Lett. 17 193 PMID: 17035009

Montarolo et al (2014) Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9 e108791 PMID: 25265488

If you know of a relevant reference for IP7e, please let us know.

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Keywords: IP7e, IP7e supplier, potent, Nurr1, activators, activates, orally, bioavailable, multiple, sclerosis, MS, EAE, experimental, autoimmune, encephalomyelitis, brain, penetrant, NF-KB, κ, signaling, isoxazolo-pyridinone, 7e, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5699, Tocris Bioscience

Citations for IP7e

Citations are publications that use Tocris products.

Currently there are no citations for IP7e. Do you know of a great paper that uses IP7e from Tocris? Please let us know.

Reviews for IP7e

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for IP7e

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.