Home / Pharmacology / Enzymes / Transferases / Protein Arginine Methyltransferases / Protein Arginine Methyltransferase Inhibitors / MS 023 dihydrochloride

MS 023 dihydrochloride

Cat. No. 5713 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective type I PRMT inhibitor
Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MS 023 dihydrochloride

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

External Portal Information for MS 023 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

Technical Data for MS 023 dihydrochloride

M. Wt 360.32
Formula C17H25N3O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1992047-64-9
PubChem ID 121513886
InChI Key HCNXCUFNZWGILO-UHFFFAOYSA-N
Smiles CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MS 023 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.03 100
DMSO 36.03 100

Preparing Stock Solutions for MS 023 dihydrochloride

The following data is based on the product molecular weight 360.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.88 mL 27.75 mL
5 mM 0.56 mL 2.78 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for MS 023 dihydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for MS 023 dihydrochloride

References are publications that support the biological activity of the product.

Eram et al (2016) A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 11 772 PMID: 26598975

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 11 19 PMID: 30604761

If you know of a relevant reference for MS 023 dihydrochloride, please let us know.

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Keywords: MS 023 dihydrochloride, MS 023 dihydrochloride supplier, MS023, dihydrochloride, potent, Type-1, selective, PRMT, inhibitors, inhibits, PRMT6, PRMT8, PRMT1, PRMT4, PRMT3, Protein, Arginine, Methyltransferases, 5713, Tocris Bioscience

3 Citations for MS 023 dihydrochloride

Citations are publications that use Tocris products. Selected citations for MS 023 dihydrochloride include:

Tang et al (2022) A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 38 110417 PMID: 35196489

Lu et al (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell PMID: 34171309

Choucair et al (2019) The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer. Oncogene 38 4015 PMID: 30692633

Do you know of a great paper that uses MS 023 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.