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Submit ReviewCP 724714
Description: Potent and selective ErbB2 inhibitor
Chemical Name: 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for CP 724714
CP 724714 is a potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
External Portal Information for CP 724714
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP-724714 is reviewed on the chemical probes website.
Technical Data for CP 724714
| M. Wt | 469.53 |
| Formula | C27H27N5O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 383432-38-0 |
| PubChem ID | 9874913 |
| InChI Key | LLVZBTWPGQVVLW-SNAWJCMRSA-N |
| Smiles | CC1=CC(NC2=NC=NC3=CC=C(/C=C/CNC(COC)=O)C=C32)=CC=C1OC4=CC=C(C)N=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 724714
References for CP 724714
References are publications that support the biological activity of the product.
Jani et al (2007) Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67 9887 PMID: 17942920
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