Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewWL 47 - dimer
Description: High affinity caveolin-1 ligand
Biological Activity for WL 47 - dimer
WL 47 - dimer is a high affinity caveolin-1 (CAV1) ligand (Kd = 23 nM); disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL.
Licensing Information
Sold with kind permission of Professor Gregory Weiss
Technical Data for WL 47 - dimer
| M. Wt | 1844.3 |
| Formula | C80H130N24O18S4 |
| Sequence |
CSWMRLK CSWMRLK* (Modifications: Disulfide Bridge = 1-1*) |
| Storage | Store at -20°C |
| PubChem ID | 123773278 |
| InChI Key | DNQUEMNLAOMZEO-HFXGPFCTSA-N |
| Smiles | [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WL 47 - dimer
References for WL 47 - dimer
References are publications that support the biological activity of the product.
Gilliam et al (2016) Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J.Med.Chem. 59 4019 PMID: 27010220
View Related Products by Target
Keywords: WL 47 - dimer, WL 47 - dimer supplier, WL47, dimer, high, affinity, selective, caveolin-1, CAV1, ligands, oligomerization, disrupts, Endocytosis, 5978, Tocris Bioscience
Citations for WL 47 - dimer
Citations are publications that use Tocris products.
Currently there are no citations for WL 47 - dimer.
Reviews for WL 47 - dimer
There are currently no reviews for this product. Be the first to review WL 47 - dimer and earn rewards!
Have you used WL 47 - dimer?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.