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CP 673451

Cat. No. 5993 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PDGFR inhibitor
Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CP 673451

CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information for CP 673451

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Compound Libraries for CP 673451

CP 673451 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CP 673451

M. Wt 417.5
Formula C24H27N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 343787-29-1
PubChem ID 10158940
InChI Key DEEOXSOLTLIWMG-UHFFFAOYSA-N
Smiles COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 673451

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.35 20

Preparing Stock Solutions for CP 673451

The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.98 mL 59.88 mL 119.76 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
2 mM 1.2 mL 5.99 mL 11.98 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

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Product Datasheets for CP 673451

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for CP 673451

References are publications that support the biological activity of the product.

Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896

If you know of a relevant reference for CP 673451, please let us know.

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1 Citation for CP 673451

Citations are publications that use Tocris products. Selected citations for CP 673451 include:

Stacey M et al (2021) A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell 28 315-330.e5 PMID: 33181078

Do you know of a great paper that uses CP 673451 from Tocris? Please let us know.

Reviews for CP 673451

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.