Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTaltirelin
Discontinued Product
2672 has been discontinued.
View all Thyrotropin-Releasing Hormone Receptors products.
Description: Synthetic thyrotropin-releasing hormone analog
Alternative Names: TA 0910
Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
Purity: ≥96% (HPLC)
Biological Activity for Taltirelin
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
Technical Data for Taltirelin
| M. Wt | 405.41 |
| Formula | C17H23N7O5 |
| Storage | Store at -20°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 103300-74-9 |
| PubChem ID | 114750 |
| InChI Key | LQZAIAZUDWIVPM-SRVKXCTJSA-N |
| Smiles | CN(C(C[C@@H]([C@@](N[C@@H](CC3=CNC=N3)C(N2[C@H]([C@](N)=O)CCC2)=O)=O)N1)=O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Taltirelin
References for Taltirelin
References are publications that support the biological activity of the product.
Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130 PMID: 2115588
Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601 PMID: 12467901
Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403 PMID: 17220907
View Related Products by Target
View Related Products by Product Action
Keywords: Taltirelin, Taltirelin supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, TA, 0910, Thyrotropin-Releasing, Hormone, 2672, Tocris Bioscience
1 Citation for Taltirelin
Citations are publications that use Tocris products. Selected citations for Taltirelin include:
Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120 PMID: 23087672
Reviews for Taltirelin
Average Rating: 5 (Based on 1 Review.)
Have you used Taltirelin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
good quality.
By
Anonymous on 01/05/2018
Assay Type: Ex Vivo
Species: Mouse
calcium imaging