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Submit Review4,9-Anhydrotetrodotoxin
Discontinued Product
6159 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Potent and selective Nav1.6 channel blocker
Alternative Names: 4,9-anhydro-TTX
Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Purity: ≥98% (HPLC)
Biological Activity for 4,9-Anhydrotetrodotoxin
4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
Technical Data for 4,9-Anhydrotetrodotoxin
| M. Wt | 301.25 |
| Formula | C11H15N3O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 13072-89-4 |
| PubChem ID | 11243537 |
| InChI Key | STNXQECXKDMLJK-PZKHIREQSA-N |
| Smiles | O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 4,9-Anhydrotetrodotoxin
References for 4,9-Anhydrotetrodotoxin
References are publications that support the biological activity of the product.
Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141
Hargus et al (2013) Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036
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Keywords: 4,9-Anhydrotetrodotoxin, 4,9-Anhydrotetrodotoxin supplier, Na+, channel, blockers, sodium, Nav, 1.6, channels, voltage-gated, voltage-dependent, potent, selective, ttx, 4,9-anhydro-TTX, Voltage-gated, Sodium, Channels, 6159, Tocris Bioscience
4 Citations for 4,9-Anhydrotetrodotoxin
Citations are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:
Vysokov et al (2019) The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep 9 12915 PMID: 31501450
Darik A et al (2022) NaV1.1 is essential for proprioceptive signaling and motor behaviors. Elife 11 PMID: 36278870
Ellen A et al (2019) Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci 39 7086-7101 PMID: 31300524
Mohammed A et al (2020) An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain 161 1100-1108 PMID: 31929383
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