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Submit ReviewMesulergine hydrochloride
Description: 5-HT2A and 5-HT2C antagonist; also D2-like partial agonist
Alternative Names: CU-32-085
Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Mesulergine hydrochloride
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
Technical Data for Mesulergine hydrochloride
| M. Wt | 398.95 |
| Formula | C18H26N4O2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 72786-12-0 |
| PubChem ID | 155746 |
| InChI Key | HANSYUJEPWNHIM-IVMONYBCSA-N |
| Smiles | CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mesulergine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.9 | 100 | |
| water | 1.99 | 5 with gentle warming |
Preparing Stock Solutions for Mesulergine hydrochloride
The following data is based on the product molecular weight 398.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.53 mL | 25.07 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for Mesulergine hydrochloride
References for Mesulergine hydrochloride
References are publications that support the biological activity of the product.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Marko (1984) DA agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 101 263 PMID: 6468500
Markstei (1983) Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 95 101 PMID: 6230246
If you know of a relevant reference for Mesulergine hydrochloride, please let us know.
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Keywords: Mesulergine hydrochloride, Mesulergine hydrochloride supplier, 5-HT2A, 5-HT2C, 5-HT, serotonin, antagonists, D2, dopamine, partial, agonists, antiprolactin, antiParkinsonian, CU-32-085, Receptors, Non-selective, Dopamine, 1644, Tocris Bioscience
2 Citations for Mesulergine hydrochloride
Citations are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:
Moutkine et al (2017) Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem 292 6352 PMID: 28258217
Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Neurotoxicology 9 e0004063 PMID: 26367744
Do you know of a great paper that uses Mesulergine hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.