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Submit ReviewDynamin inhibitory peptide, myristoylated (control)
Description: Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775)
Biological Activity
Dynamin inhibitory peptide, myristoylated (control) is a control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.
Active Analog also available.
Technical Data
| M. Wt | 1330.64 |
| Formula | C61H107N19O14 |
| Sequence |
QPPASNPRVR (Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| PubChem ID | 90488709 |
| InChI Key | LRWOEJTUKITZIW-ZUSDHBTASA-N |
| Smiles | [H]N([C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(=O)CCCCCCCCCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966
Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117
Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920
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Keywords: Dynamin inhibitory peptide, myristoylated (control), Dynamin inhibitory peptide, myristoylated (control) supplier, 1775, Mitosis, Dynamin, Epac, GTPases, 1776, Tocris Bioscience
3 Citations for Dynamin inhibitory peptide, myristoylated (control)
Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated (control) include:
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neuroinflammation 10 e0131430 PMID: 26102354
Westmark et al (2010) Pin1 and PKMzeta sequentially control dendritic protein synthesis. Sci Signal 3 ra18 PMID: 20215645
Wang et al (2017) The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. J Neurosci 37 7096 PMID: 28630256
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