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Submit ReviewHU 211
Description: NMDA receptor antagonist; also NF-κB inhibitor
Alternative Names: Dexanabinol
Chemical Name: (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
Purity: ≥97% (HPLC)
Biological Activity for HU 211
HU 211 is a NMDA antagonist (IC50 = 11 μM for inhibition of [3H]MK-801 binding to rat forebrain membranes). Protects against NMDA- and quisqualate-induced neurotoxicity (EC50 = 3.8 μM) and enhances dopamine D1 receptor activity. Inhibits NF-κB, reducing TNF-α, IL-6 and nitric oxide production, and acts as a free radical scavenger. Exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant.
Technical Data for HU 211
| M. Wt | 386.57 |
| Formula | C25H38O3 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 112924-45-5 |
| PubChem ID | 107778 |
| InChI Key | SSQJFGMEZBFMNV-PMACEKPBSA-N |
| Smiles | CCCCCCC(C)(C)C1=CC(O)=C([C@]2([H])[C@](C(C)(C)O3)([H])CC=C(CO)C2)C3=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for HU 211
References for HU 211
References are publications that support the biological activity of the product.
Eshhar et al (1993) HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture. Neuroreport 5 237 PMID: 8298080
Striem et al (1997) Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the DArgic system. Eur.J.Pharmacol. 338 205 PMID: 9424014
Gallily et al (1997) Protection against septic shock and suppression of tumor necrosis factor α and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J.Pharmacol.Exp.Ther. 283 918 PMID: 9353414
Juttler et al (2004) The cannabinoid dexanabinol is an inhibitor of the nuclear factor kappa B (NF-κB). Neuropharmacology 47 580 PMID: 15380375
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Keywords: HU 211, HU 211 supplier, NF-κB, NF-kappaB, NF-kB, inhibitors, inhibits, decreases, TNF-α, TNF-alpha, IL-6, NO, production, NMDA, antagonists, receptors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, HU211, Dexanabinol, NF-kB/IkB, 2861, Tocris Bioscience
Citations for HU 211
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Currently there are no citations for HU 211.
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