Akt Signaling Pathway
RTK Apoptosis Integrin
Receptor Cytokine
Receptor PI3K PI3K PI3K PI3K FAK Src JNK mTOR mTOR p70
S6K GSK-3 IKK IκB p53 p53 β-catenin NF-κB NF-κB GABAA
Receptor eNOS PDK1 Caspase-9 PP2A Akt Akt Bcl-XL Bax Protein Synthesis GPCR Cell Cycle Cytokines Integrins Growth
Factors
Receptor Cytokine
Receptor PI3K PI3K PI3K PI3K FAK Src JNK mTOR mTOR p70
S6K GSK-3 IKK IκB p53 p53 β-catenin NF-κB NF-κB GABAA
Receptor eNOS PDK1 Caspase-9 PP2A Akt Akt Bcl-XL Bax Protein Synthesis GPCR Cell Cycle Cytokines Integrins Growth
Factors
The Akt/PI 3-Kinase signaling pathway is involved in fundamental cellular processes including protein synthesis, proliferation and survival. PI 3-kinase is activated following ligand binding to a range of receptors which activates Akt downstream, phosphorylating a wide range of substrates and initiating cellular events.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Translocates
Kinase
Transcription Factor
Enzyme-linked Receptor
Other Enzyme
Other Protein
Phosphatase
Proapoptotic
Prosurvival
7-TM Receptor
