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CRF1 Receptors

The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS, with major expression in the cortex, cerebellum, hippocampus and amygdala.

Products
Background
Literature (1)
Gene Data

CRF1 Receptor Agonists
Cat. No. Product Name / Activity
1608 Stressin I
CRF1 agonist

CRF1 Receptor Antagonists
Cat. No. Product Name / Activity
2778 Antalarmin hydrochloride
CRF1 antagonist
2779 CP 154526
Selective, non-peptide CRF1 antagonist
3212 CP 376395 hydrochloride
Potent and selective CRF1 antagonist; binds at an allosteric site
1591 NBI 27914 hydrochloride
Selective non-peptide CRF1 antagonist
3100 NBI 35965 hydrochloride
Potent and selective CRF1 antagonist
6451 Pexacerfont
Potent and selective CRF1 antagonist; anxiolytic
6530 R 121919 hydrochloride
High affinity CRF1 antagonist; orally bioavailable

Related Targets

    The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland.

    External sources of pharmacological information for CRF1 Receptors :

    Literature for CRF1 Receptors

    Tocris offers the following scientific literature for CRF1 Receptors to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Depression Poster

    Depression Poster

    Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

    CRF1 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human CRHR1 NM_004382 P34998
    Mouse Crhr1 NM_007762 P35347
    Rat Crhr1 NM_030999 P35353